Evidence-based practice (EBP) or evidence-based medicine (EBM) is defined as "...the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients. The practice of evidence based medicine means integrating individual clinical expertise with the best available external clinical evidence from systematic research."
Sackett DL, Rosenberg WM, Gray JA, Haynes RB, Richardson WS. Evidence based medicine: what it is and what it isn’t. BMJ:British Medical Journal. 1996;312(7023):71-72.
PICO is a mnemonic designed to help you remember the parts of a well-formed clinical question.
Patient: How would you describe your patient or a similar population?
Intervention: What intervention are you considering for this patient or population?
Comparison: What is the gold standard or an alternative treatment for this patient?
Outcome: What do you hope to achieve, measure, affect?