The De Mesa-Sánchez House is a restored example of two First Spanish Period (1565-1763) homes. The first known owner, Antonio de Mesa, built a one-story, one-room coquina structure on the property around 1740. During the British Period (1764-1784), the home was used as a governmental office, and several rooms were added. Don Juan Sánchez purchased the home in 1784 and added its second story. In the 1950s, the home was remodeled as a northern Spanish Inn. The De Mesa-Sánchez House was then acquired by the State of Florida in 1977 and restored to its American Territorial Period (1821-1845) appearance.
The full Wikipedia entry for the De Mesa Sanchez House is available here.